Results
| PMID | 15104227 |
| Gene Name | FASLG |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 50 |
| Population details | 50 (20 infertile patients with endometriosis, 14 infertile patients due to chronic pelvic infectious disease , 16 fertile controls) |
| Sex | Female |
| Infertility type | Female infertility |
| Associated genes | FasL |
| Other associated phenotypes |
Female infertility with endometriosis |
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Chin Med Sci J. 2004 Mar;19(1):56-9. Linghu, Hua| Xu, Xiaorong| Luo, Jianyun| Zhuang, Lin Department of Obstetrics and Gynecology, First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400012. OBJECTIVE: To evaluate the relationship between levels of soluble Fas (sFas) and soluble Fas ligand (sFasL) in serum and peritoneal fluid of endometriosis-associated infertility. METHODS: The soluble Fas ligand and soluble Fas levels in serum and peritoneal fluid of 20 infertile patients with endometriosis were assessed with enzyme-linked immunosorbent assay, and were compared with 14 infertile patients due to chronic pelvic infectious disease and 16 fertile controls. RESULTS: The sFasL levels were significantly higher in infertile patients with endometriosis (175.09 +/- 80.55 pg/mL in serum and 284.50 +/- 152.38 pg/mL in peritoneal fluid) than those of infertile controls (88.47 +/- 43.55 pg/mL in serum and 17.30 +/- 9.62 pg/mL in peritoneal fluid) and fertile controls (16.13 +/- 11.75 pg/mL in serum and 8.84 +/- 2.31 pg/mL in peritoneal fluid). In contrast, as for the sFas levels, infertile patients with endometriosis (828.60 +/- 429.65 pg/mL in serum and 349.61 +/- 288.89 pg/mL in peritoneal fluid) did not show any significant difference compared with those in infertile patients resulting from pelvic infectious disease (868.75 +/- 570.48 pg/mL in serum and 181.76 +/- 157.78 pg/mL in peritoneal fluid) and fertile control (822.26 +/- 129.12 pg/mL in serum and 318.42 +/- 145.16 pg/mL in peritoneal fluid). CONCLUSIONS: Based upon these results, high level of sFasL in serum and peritoneal fluid and thus apoptosis mediated by it may be implicated in the mechanism involved in endometriosis-related infertility. Mesh Terms: Antigens, CD95/blood/*metabolism| Ascitic Fluid/*chemistry| Endometriosis/complications/*metabolism| Fas Ligand Protein| Female| Humans| Infertility, Female/etiology/*metabolism| Ligands| Membrane Glycoproteins/blood/*metabolism| Pelvic Infection |
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